Biography

Nilesh received Bachelor of Pharmacy (2002) and Master of Business Administration (2004) from Pune University, India. Nilesh moved to Skovde University, Sweden for Masters in Science with specialization in Molecular Biology (2006) with thesis research performed at University of Würzburg, Germany understanding the role of angiotensin II type 1 receptor blockage to prevent the oxidative stress induced genomic damage by Angiotensin II in kidney cells. In 2011 he was awarded PhD from Aberdeen University for his doctoral research in the area of oxidative stress and potential natural antioxidant defence by Curcumin on the survival and functioning of cultured pancreatic β-islet cells. Nilesh joined School of Life Sciences, Nano-Safety Research Group at Heriot-Watt University in 2011 and later moved over to School of Engineering and Physical Sciences (EPS), Institute of Biological Chemistry, Biophysics and Bioengineering (IB3) in 2016.
Nilesh has been part of several research projects working in collaboration with various international partners: Inlivetox,Nanomicex, Colt, Nanochop, Qnano. He is well experienced with cell toxicity assays including: Alamar blue, LDH, MTT, WST as well as techniques like RTQ-PCR; ELISA; and FACS. Nilesh is also involved in inter-disciplinary projects with the School of Energy, Geoscience, Infrastructure and Society (EGIS), Institute of Life and Earth Sciences at Heriot-Watt University. Past collaborations included projects investigating the use of microcantilever biosensors as a novel method for the assessment of nanomaterial toxicity, the development of new techniques for 3D imaging of nanomaterials, and the development and testing of novel cell culture surfaces. Currently he is working on EPSRC funded project to develop a rapid, low-cost nanotoxicology screening in microdroplets to address the global need for high throughput testing. He is also working on the EU 7th Framework Programme funded Sustainable Nanotechnologies (SUN) project. Dr. Nilesh is also responsible for the efficient implementation of the University’s legal responsibilities in relation to health and safety.

Training courses:

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Awards and Grants:

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Conferences:

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Selected Publications

Mechanism of neutrophil activation and toxicity elicited by engineered nanomaterials. Johnston H, Brown DM, Kanase N, Euston M, Gaiser BK, Robb CT, Dyrynda E, Rossi AG, Brown ER, Stone V, Toxicology in Vitro, 2015, 29( 5), 1172–1184
The role of Kupffer cells in the hepatic response to silver nanoparticles. Kermanizadeh A, Chauché C, Balharry D, Brown DM, Kanase N, Boczkowski J, Lanone S, Stone V, Nanotoxicology, 2014, 8 Suppl 1:149-154
3) Inflammation and gene expression in the rat lung after instillation of silica nanoparticles : effect of size, dispersion medium and particle surface charge. Brown DM, Kanase N, Gaiser B, Johnston H, Stone V, Toxicology Letters 2014, 224(1):147-156
4) Effects of silver nanoparticles on the liver and hepatocytes in vitro. Gaiser BK, Hirn S, Kermanizadeh A, Kanase N, Fytianos K, Wenk A, Haberl N, Brunelli A, Kreyling WG, Stone V, Toxicological Sciences, 2013, 131(2):537-547
5) Angiotensin II-induced genomic damage in renal cells can be prevented by angiotensin II type 1 receptor blockage or radical scavenging. Schupp N, Schmid U, Rutkowski P, Lakner U, Kanase N, Heidland A, Stopper H, American journal of physiology: Renal physiology, 2007, 292(5):F1427-1434